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Apr, 2024
Novel combination therapy for treating proteasome inhibitor-resistant multiple myeloma
AACR 2024Apr, 2024
Oral TGF-beta receptor1 inhibitor, Vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti-tumor immunity
AACR 2024Feb, 2024
Clinical activity of transforming growth factor-β inhibitor vactosertib in combination 3 with imatinib in desmoid tumors: a multicenter phase Ib/II study
Clinical Cancer ResearchNov, 2023
A Competitive Inhibitor of MOART Showed Potent Therapeutic Effects in a Mouse Model of Collagen-induced Arthritis
미국류마티스학회 2023(ACR 2023)Oct, 2023
Efficacy and Safety of Vactosertib and Pembrolizumab Combination in Patients with Previously Treated Microsatellite Stable Metastatic Colorectal Cancer
유럽종양학회(ESMO)Apr, 2023
Vactosertib combined treatment with T1-44, a PRMT5 activity inhibitor, improves the survival and inhibits tumor invasion of murine pancreatic cancer model
American Association for Cancer Research 2023(AACR 2023)Feb, 2023
Combination treatment of T1-44, a PRMT5 inhibitor with Vactosertib, an inhibitor of TGF-β signaling, inhibits invasion and prolongs survival in a mouse model of pancreatic tumors
Cell Death and Disease (2023)Jan, 2023
Discovery of TRD-93 as a novel DRAK2 inhibitor
BULLETIN OF THE KOREAN CHEMICAL SOCIETYDec, 2022
MAST4 controls cell cycle in spermatogonial stem cells
Cell proliferation(IF : 8.755)Dec, 2022
Therapeutic Implications of TGF-β Pathway in Desmoid Tumor Based on Comprehensive Molecular Profiling and Clinicopathological Properties
CancersOct, 2022
ESRP1-regulated isoform switching of LRRFIP2 determines metastasis of gastric cance
Nature communicationSep, 2022
Phase 1b Study of Vactosertib in Combination with FOLFOX in Patients with Metastatic Pancreatic Ductal Adenocarcinoma who have Failed First-Line Gemcitabine/nab-Paclitaxel
미국암연구학회 췌장암 특별 컨퍼런스(AACR Special Conference on Pancreatic Cancer)2022Jan, 2022
Phase 1b Study of Vactosertib in Combination with nal-IRI plus 5FU/LV in Patients with Metastatic Pancreatic Ductal Adenocarcinoma who Failed First-Line Gemcitabine/nab-Paclitaxel
미국임상종양학회 위장관종양심포지엄(ASCO GI) 2022Nov, 2021
Tumor Microenvironment based on PD-L1 and CD8 T-cell infiltration correlated with the survival of MSS mCRC patients treated vactosertib in combination with pembrolizumab
미국 면역항암학회(SITC) 2021Nov, 2021
Spatial analysis of tumor-infiltrating lymphocytes correlates with the response of metastatic colorectal cancer patients treated with vactosertib in combination with pembrolizumab
미국 면역항암학회(SITC) 2021Jun, 2021
Efficacy and Safety of Vactosertib and Pembrolizumab Combination in Patients with Previously Treated Microsatellite Stable Metastatic Colorectal Cancer
미국임상종양학회(ASCO) 2021Jun, 2021
Phase 1b trial of Vactosertib in Combination with Pomalidomide in Relapsed Multiple Myeloma: A Corticosteroid-Free Approach by Targeting TGF-β Signaling Pathway
미국임상종양학회(ASCO) 2021Apr, 2021
BAG2 Promotes Tumorigenesis and Metastasis by Regulating the Cathepsin B Cleavage in Triple Negative Breast Cancer Cells
미국 암학회(AACR) 2021Apr, 2021
DRAK1 suppresses inflammation induced cervical cancer progression by targeting TRAF6 protein
미국 암학회 (AACR) 2021Apr, 2021
Beneficial effect of vactosertib combined with nal IRI5 FULV in pancreatic cancer treatment
미국 암학회 (AACR) 2021Apr, 2021
Genomic and transcriptomic analyses of desmoid tumor reveals enrichment of transforming growth factor beta responsive signature
미국 암학회 (AACR) 2021Nov, 2020
Vactosertib and Durvalumab as Second or Later Line Treatment for PD-L1 Positive Non-small Cell Lung Cancer: Interim Result
미국 면역항암학회 (SITC) 2020Sep, 2020
Safety and Efficacy of Vactosertib, a TGFBR1 Kinase Inhibitor, in Combination with Paclitaxel in Patients with Metastatic Gastric Adenocarcinoma
유럽종양학회 연례회의 (ESMO) Congress 2020May, 2020
A Phase 1 study of TGF-β inhibitor, Vactosertib, in combination with Imatinib in patients with advanced desmoid tumor (aggressive fibromatosis)
미국임상종양학회 (ASCO) 2020Nov, 2019
Safety and Preliminary clinical activity of Vactosertib, a selective TGF-β receptor I kinase inhibitor, in combination with Durvalumab in advanced Non-small cell lung cancer patients with low PD-L1 expression
미국면역암학회 (SITC) 2019Nov, 2019
Safety and preliminary clinical activity of Vactosertib, a selective TGF-β receptor I kinase inhibitor, in combination with Pembrolizumab in patients with metastatic colorectal or gastric cancer
미국면역암학회 (SITC) 2019Nov, 2019
TGF-β as a promising therapeutic target for treating Osteosarcoma
Innovation in AYA cancer